High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer.

ABSTRACT:

Background

The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infiltration in breast cancer (BRCA) remain uncertain.

Methods

Oncomine, Timer and UALCAN were used to analyze the expression of eIF4E in various cancers. PrognoScan, Kaplan-Meier plotter, and GEPIA were utilized to analyze the prognostic value of eIF4E in select cancers. In vitro cell experiments were used to verify the role of eIF4E in promoting the progression of BRCA. ImmuCellAI and TIMER database were used to explore the relationship between eIF4E and tumor infiltrating immune cells. The expression of a macrophage marker (CD68⁺) and a

SUBMITTER: Li F 

PROVIDER: S-EPMC8650334 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature