Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression.

ABSTRACT:

Background

Depression is a severe neuropsychiatric disorder that affects more than 264 million people worldwide. The efficacy of conventional antidepressants are barely adequate and many have side effects. Hericium erinaceus (HE) is a medicinal mushroom that has been reported to have therapeutic potential for treating depression.

Methods

Animals subjected to chronic restraint stress were given 4 weeks HE treatment. Animals were then screened for anxiety and depressive-like behaviours. Gene and protein assays, as well as histological analysis were performed to probe the role of neurogenesis in mediating the therapeutic effect of HE. Temozolomide was administered to validate the neurogenesis-dependent mechanism of HE.

Results

The results showed that 4 weeks of HE treatm

SUBMITTER: Chong PS 

PROVIDER: S-EPMC8650354 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature