Increasing power in the analysis of responder endpoints in rheumatology: a software tutorial.

ABSTRACT:

Background

Composite responder endpoints feature frequently in rheumatology due to the multifaceted nature of many of these conditions. Current analysis methods used to analyse these endpoints discard much of the data used to classify patients as responders and are therefore highly inefficient, resulting in low power. We highlight a novel augmented methodology that uses more of the information available to improve the precision of reported treatment effects. Since these methods are more challenging to implement, we developed free, user-friendly software available in a web-based interface and as R packages. The software consists of two programs: one that supports the analysis of responder endpoints; the second that facilitates sample size estimation. We demonstrate the use of the so

SUBMITTER: McMenamin M 

PROVIDER: S-EPMC8650391 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature