Five crucial prognostic-related autophagy genes stratified female breast cancer patients aged 40-60 years.

ABSTRACT:

Background

Autophagy is closely related to the progression of breast cancer. The aim at this study is to establish a prognostic-related model comprised of hub autophagy genes (AGs) to assess patient prognosis. Simultaneously, the model can guide clinicians to make up individualized strategies and stratify patients aged 40-60 years based on risk level.

Methods

The hub AGs were identified with univariate COX regression and LASSO regression. The functions and alterations of these selected AGs were analyzed as well. Moreover, the multivariate COX regression and correlation analysis between hub AGs and clinicopathological parameters were done.

Results

Totally, 33 prognostic-related AGs were obtained from the univariate COX regression (P < 0.05). SERPINA1, HSPA8, HSPB8, MAP

SUBMITTER: Li X 

PROVIDER: S-EPMC8650421 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature