Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is imperative to develop successful therapeutic agents.

Methods

The anti-proliferative effect of ivermectin on ESCC is investigated in cell model and in nude mice model. Cell apoptosis was assessed using flow cytometry, TUNEL assay and western blotting. Mitochondrial dysfunction was determined by reactive oxygen species accumulation, mitochondrial membrane potential and ATP levels.

Results

Our results determined that ivermectin significantly inhibited the proliferation of ESCC cells in vitro and in vivo. Furthermore, we found that ivermectin markedly mediated

SUBMITTER: Xu N 

PROVIDER: S-EPMC8650430 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature