Hepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection.

ABSTRACT:

Background

Chronic hepatitis B virus (HBV) infection (CHB) is a significant public health problem that could benefit from treatment with immunomodulators. Here we describe a set of therapeutic HBV vaccines that target the internal viral proteins.

Methods

Vaccines are delivered by chimpanzee adenovirus vectors (AdC) of serotype 6 (AdC6) and 7 (AdC7) used in prime only or prime-boost regimens. The HBV antigens are fused into an early T cell checkpoint inhibitor, herpes simplex virus (HSV) glycoprotein D (gD), which enhances and broadens vaccine-induced cluster of differentiation (CD8)⁺ T cell responses.

Results

Our results show that the vaccines are immunogenic in mice. They induce potent CD8⁺ T cell responses that recognize multiple epitopes. CD8<

SUBMITTER: Hasanpourghadi M 

PROVIDER: S-EPMC8650432 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature