Probing Isoform Switching Events in Various Cancer Types: Lessons From Pan-Cancer Studies.

ABSTRACT: Alternative splicing is an essential regulatory mechanism for gene expression in mammalian cells contributing to protein, cellular, and species diversity. In cancer, alternative splicing is frequently disturbed, leading to changes in the expression of alternatively spliced protein isoforms. Advances in sequencing technologies and analysis methods led to new insights into the extent and functional impact of disturbed alternative splicing events. In this review, we give a brief overview of the molecular mechanisms driving alternative splicing, highlight the function of alternative splicing in healthy tissues and describe how alternative splicing is disrupted in cancer. We summarize current available computational tools for analyzing differential transcript usage, isoform switching events, an

SUBMITTER: Karakulak T 

PROVIDER: S-EPMC8650491 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature