MicroRNA signatures in plasma and plasma exosome during window of implantation for implantation failure following in-vitro fertilization and embryo transfer.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small, non-coding RNAs that are dysregulated in many diseases and can act as biomarkers. Although well-studied in cancer, the role of miRNAs in embryo implantation is poorly understood. Approximately 70% of embryos fail to implant following in-vitro fertilization and embryo transfer, 10% of patients experienced recurrent implantation failure. However, there are no well-established biomarkers that can predict implantation failure. Our purpose is to investigate distinct miRNA profiles in plasma and plasma exosomes during the window of implantation between patients with failed implantation and successful implantation.

Methods

We select a nested case-control population of 12 patients with implantation failure or successfully clinical pregnancy u

SUBMITTER: Zeng H 

PROVIDER: S-EPMC8650536 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature