Investigating the Transcriptome of Candida albicans in a Dual-Species Staphylococcus aureus Biofilm Model.

ABSTRACT: Candida albicans is an opportunistic pathogen found throughout multiple body sites and is frequently co-isolated from infections of the respiratory tract and oral cavity with Staphylococcus aureus. Herein we present the first report of the effects that S. aureus elicits on the C. albicans transcriptome. Dual-species biofilms containing S. aureus and C. albicans mutants defective in ALS3 or ECE1 were optimised and characterised, followed by transcriptional profiling of C. albicans by RNA-sequencing (RNA-seq). Altered phenotypes in C. albicans mutants revealed specific interaction profiles between fungus and bacteria. The major adhesion and virulence proteins Als3 and Ece1, respectively, were found to have substantial effe

SUBMITTER: Short B 

PROVIDER: S-EPMC8650683 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature