Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy.

ABSTRACT: Atherosclerosis is associated with various pathological manifestations, such as ischemic heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading cause of public health concern. Atherosclerosis is an inflammatory disease characterized by endothelial dysfunction; vascular inflammation; and the deposition of lipids, cholesterol, calcium, and cellular debris within the vessel wall intima. In-depth studies of gut flora in recent years have shown that bacterial translocation and the existence of bacterial active products in blood circulation can affect the inflammatory state of the whole blood vessel. The gut flora is considered to be a large "secretory organ," which produces trimethylamine-N-oxide (TMAO), short-chain fatty acids and secondary bile acids by breakin

SUBMITTER: Wang B 

PROVIDER: S-EPMC8650703 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature