Effects of Alcohol Binge Drinking and Oleoylethanolamide Pretreatment in the Gut Microbiota.

ABSTRACT:

Introduction

Chronic alcohol consumption is known to cause gut dysbiosis (changes in microbiota composition and/or function, disruptive of the normal host-microbiota interactions). However, little is known about the changes that alcohol binge drinking induces in the gut microbiota. Here, we have tested the hypothesis that a protocol of alcohol binge drinking, known to induce neuroinflammation in previous studies, also promotes intestinal dysbiosis, and we explored how oleoylethanolamide (OEA, an acylethanolamide proven to counteract alcohol binge drinking-induced neuroinflammation) pretreatment modulates alcohol-induced dysbiosis.

Methods

Alcohol binges were forced by gavage three times per day during 4 consecutive days; OEA pretreatment (intraperitoneal or intragastric) was

SUBMITTER: Rodriguez-Gonzalez A 

PROVIDER: S-EPMC8651011 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature