Cells with Cancer-associated Mutations Overtake Our Tissues as We Age.

ABSTRACT:

Background

To shed light on the earliest events in oncogenesis, there is growing interest in understanding the mutational landscapes of normal tissues across ages. In the last decade, next-generation sequencing of human tissues has revealed a surprising abundance of cells with what would be considered oncogenic mutations.

Aims

We performed meta-analysis on previously published sequencing data on normal tissues to categorize mutations based on their presence in cancer and showcase the quantity of cells with cancer-associated mutations in cancer-free individuals.

Methods and results

We analyzed sequencing data from these studies of normal tissues to determine the prevalence of cells with mutations in three different categories across multiple age groups: 1) mutations in

SUBMITTER: Evans EJ 

PROVIDER: S-EPMC8651076 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature