Engineered Cytokines for Cancer and Autoimmune Disease Immunotherapy.

ABSTRACT: Cytokine signaling is critical to a range of biological processes including cell development, tissue repair, aging, and immunity. In addition to acting as key signal mediators of the immune system, cytokines can also serve as potent immunotherapies with more than 20 recombinant products currently Food and Drug Administration (FDA)-approved to treat conditions including hepatitis, multiple sclerosis, arthritis, and various cancers. Yet despite their biological importance and clinical utility, cytokine immunotherapies suffer from intrinsic challenges that limit their therapeutic potential including poor circulation, systemic toxicity, and low tissue- or cell-specificity. In the past decade in particular, methods have been devised to engineer cytokines in order to overcome such challenges and

SUBMITTER: Uricoli B 

PROVIDER: S-EPMC8651077 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature