Topography of hippocampal connectivity with sensorimotor cortex revealed by optimizing smoothing kernel and voxel size.

ABSTRACT: Studies of the hippocampus use smaller voxel sizes and smoothing kernels than cortical activation studies, typically using a multivoxel seed with specified radius for connectivity analysis. This study identified optimal processing parameters for evaluating hippocampal connectivity with sensorimotor cortex (SMC), comparing effectiveness by varying parameters during both activation and connectivity analysis. Using both 3mm and 4mm isovoxels, smoothing kernels of 0-10mm were evaluated on the amplitude and extent of motor activation and hippocampal connectivity with SMC. Psychophysiological interactions (PPI) identified hippocampal connectivity with SMC during volitional movements, and connectivity effects from multivoxel seeds were compared with alternate methods; a structural seed represente

SUBMITTER: Burman DD 

PROVIDER: S-EPMC8651104 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature