Prediction of sustained biologic and targeted synthetic DMARD-free remission in rheumatoid arthritis patients.

ABSTRACT:

Objectives

The aim was to develop a prediction model of sustained remission after cessation of biologic or targeted synthetic DMARD (b/tsDMARD) in RA.

Methods

We conducted an explorative cohort study among b/tsDMARD RA treatment episode courses stopped owing to remission in the Swiss Clinical Quality Management registry (SCQM; 2008-2019). The outcome was sustained b/tsDMARD-free remission of ≥12 months. We applied logistic regression model selection algorithms using stepwise, forward selection, backward selection and penalized regression to identify patient characteristics predictive of sustained b/tsDMARD-free remission. We compared c-statistics corrected for optimism between models. The three models with the highest c-statistics were validated in new SCQM data until 2020 (

SUBMITTER: Burkard T 

PROVIDER: S-EPMC8651222 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature