Prognostic Role of TIGIT Expression in Patients with Solid Tumors: A Meta-Analysis.

ABSTRACT:

Background

T cell immunoglobulin and ITIM domain (TIGIT) is a recently identified immunosuppressive receptor. The expression levels of TIGIT affect the prognosis of patients with solid tumors. To fully comprehend the role of TIGIT on the prognosis of patients with solid tumors, we conducted a meta-analysis.

Methods

We performed an online search of PubMed, Embase, Web of Science (WOS), and MEDLINE databases for literature published till March 31, 2021. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the literature, and Stata 16.0 and Engauge Digitizer 4.1 software were used for data analysis.

Results

Our literature search identified eight papers comprising 1426 patients with solid tumors. Increased expression of TIGIT was associated with poor progn

SUBMITTER: Xiao K 

PROVIDER: S-EPMC8651431 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature