Age dependency of plasma vitamin B12 status markers in Dutch children and adolescents.

ABSTRACT:

Background

Vitamin B12 deficiency in children may be associated with (severe) neurological manifestations, therefore recognition is important. Diagnosing vitamin B12 deficiency in children is challenging. This study aimed to investigate plasma methylmalonic acid, holotranscobalamin, and total cobalamin in children 0-18 years of age and to estimate age-dependent reference intervals.

Methods

Plasma vitamin B12 markers were measured in collected plasma samples of 170 children 0-18 years visiting a local primary care laboratory. All had within-reference hemoglobin and MCV values. Pediatric plasma vitamin B12 biomarkers were measured and reference values were derived thereof.

Results

Plasma methylmalonic acid was higher in young children, in particular between 1 and 6 mont

SUBMITTER: Heiner-Fokkema MR 

PROVIDER: S-EPMC8651506 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature