Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.

ABSTRACT: The cellular response to DNA damage (DDR) that causes replication collapse and/or DNA double strand breaks, is characterised by a massive change in the post-translational modifications (PTM) of hundreds of proteins involved in the detection and repair of DNA damage, and the communication of the state of damage to the cellular systems that regulate replication and cell division. A substantial proportion of these PTMs involve targeted phosphorylation, which among other effects, promotes the formation of multiprotein complexes through the specific binding of phosphorylated motifs on one protein, by specialised domains on other proteins. Understanding the nature of these phosphorylation mediated interactions allows definition of the pathways and networks that coordinate the DDR, and helps iden

SUBMITTER: Day M 

PROVIDER: S-EPMC8651625 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature