Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice.

ABSTRACT: Alzheimer's disease (AD) is associated with aberrant neuronal activity, which is believed to critically determine disease symptoms. How these activity alterations emerge, how stable they are over time, and whether cellular activity dynamics are affected by the amyloid plaque pathology remains incompletely understood. We here repeatedly recorded the activity from identified neurons in cortex of awake APPPS1 transgenic mice over four weeks during the early phase of plaque deposition using in vivo two-photon calcium imaging. We found that aberrant activity during this stage largely persisted over the observation time. Novel highly active neurons slowly emerged from former intermediately active neurons. Furthermore, activity fluctuations were independent of plaque proximity, but aberrant activ

SUBMITTER: Korzhova V 

PROVIDER: S-EPMC8651654 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature