Preclinical study of ²¹²Pb alpha-radioimmunotherapy targeting CD20 in non-Hodgkin lymphoma.

ABSTRACT:

Background

Despite therapeutic advances, Non-Hodgkin lymphoma (NHL) relapses can occur. The development of radioimmunotherapy (RIT) with α-emitters is an attractive alternative. In this study, we investigated the potential of α-RIT in conjunction with ²¹²Pb-rituximab for the treatment of NHL.

Methods

EL4-hCD20-Luc cells (mouse lymphoma cell line) were used for in vitro and in vivo studies. Biodistribution and efficacy studies were performed on C57BL/6 mice injected intravenously with 25 × 10³ cells.

Results

²¹²Pb-rituximab (0.925-7.4 kBq/mL) inhibit proliferation of EL4-hCD20-Luc cells in vitro. Biodistribution of ^203/212Pb-rituximab in mice showed a significant tumour uptake and suggested that the liver, spleen, and kidneys

SUBMITTER: Durand-Panteix S 

PROVIDER: S-EPMC8651676 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature