Personalized modulation of coagulation factors using a thrombin dynamics model to treat trauma-induced coagulopathy.

ABSTRACT: Current trauma-induced coagulopathy resuscitation protocols use slow laboratory measurements, rules-of-thumb, and clinician gestalt to administer large volumes of uncharacterized, non-tailored blood products. These one-size-fits-all treatment approaches have high mortality. Here, we provide significant evidence that trauma patient survival 24 h after hospital admission occurs if and only if blood protein coagulation factor concentrations equilibrate at a normal value, either from inadvertent plasma-based modulation or from innate compensation. This result motivates quantitatively guiding trauma patient coagulation factor levels while accounting for protein interactions. Toward such treatment, we develop a Goal-oriented Coagulation Management (GCM) algorithm, a personalized and automated or

SUBMITTER: Ghetmiri DE 

PROVIDER: S-EPMC8651743 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature