Ontology highlight
ABSTRACT:
SUBMITTER: Cutigi JF
PROVIDER: S-EPMC8651746 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Cutigi Jorge Francisco JF Evangelista Adriane Feijo AF Reis Rui Manuel RM Simao Adenilso A
Scientific reports 20211207 1
Identifying significantly mutated genes in cancer is essential for understanding the mechanisms of tumor initiation and progression. This task is a key challenge since large-scale genomic studies have reported an endless number of genes mutated at a shallow frequency. Towards uncovering infrequently mutated genes, gene interaction networks combined with mutation data have been explored. This work proposes Discovering Significant Cancer Genes (DiSCaGe), a computational method for discovering sign ...[more]