AdaTiSS: A Novel Data-Adaptive Robust Method for Identifying Tissue Specificity Scores.

ABSTRACT:

Motivation

Accurately detecting tissue specificity (TS) in genes helps researchers understand tissue functions at the molecular level. The Genotype-Tissue Expression project is one of the publicly available data resources, providing large-scale gene expressions across multiple tissue types. Multiple tissue comparisons and heterogeneous tissue expression make it challenging to accurately identify tissue specific gene expression. How to distinguish the inlier expression from the outlier expression becomes important to build the population level information and further quantify the TS. There still lacks a robust and data-adaptive TS method taking into account heterogeneities of the data.

Methods

We found that the key to identify tissue specific gene expression is to properly de

SUBMITTER: Wang M 

PROVIDER: S-EPMC8652109 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature