Relationship between depression, prefrontal creatine and grey matter volume.

ABSTRACT:

Background

Depression and low mood are leading contributors to disability worldwide. Research indicates that clinical depression may be associated with low creatine concentrations in the brain and low prefrontal grey matter volume. Because subclinical depression also contributes to difficulties in day-to-day life, understanding the neural mechanisms of depressive symptoms in all individuals, even at a subclinical level, may aid public health.

Methods

Eighty-four young adult participants completed the Depression, Anxiety and Stress Scale (DASS) to quantify severity of depression, anxiety and stress, and underwent ¹H-Magnetic Resonance Spectroscopy of the medial prefrontal cortex and structural magnetic resonance imaging (MRI) to determine whole-brain grey matter vo

SUBMITTER: Faulkner P 

PROVIDER: S-EPMC8652356 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature