Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour.

ABSTRACT:

Background

Acute stress is thought to reduce goal-directed behaviour, an effect purportedly associated with stress-induced release of catecholamines. In contrast, experimentally increased systemic catecholamine levels have been shown to increase goal-directed behaviour. Whether experimentally increased catecholamine function can modulate stress-induced reductions in goal-directed behaviour and its neural substrates, is currently unknown.

Aim

To assess whether and how experimentally induced increases in dopamine and noradrenaline contribute to the acute stress effects on goal-directed behaviour and associated brain activation.

Methods

One hundred participants underwent a stress induction protocol (Maastricht acute stress test; MAST) or a control procedure and received

SUBMITTER: van Ruitenbeek P 

PROVIDER: S-EPMC8652367 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature