Identification of potential key genes and functional role of CENPF in osteosarcoma using bioinformatics and experimental analysis.

ABSTRACT: Osteosarcoma, which arises from bone tissue, is considered to be one of the most common types of cancer in children and teenagers. As the etiology of osteosarcoma has not been fully elucidated, the overall prognosis for patients is generally poor. In recent years, the development of bioinformatical technology has allowed researchers to identify numerous molecular biological characteristics associated with the prognosis of osteosarcoma using online databases. In the present study, Gene Expression Omnibus (GEO) database was used and three microarray datasets were obtained. The GEO2R web tool was utilized and differentially expressed genes (DEGs) in osteosarcoma tissue were identified. Venn analysis was performed to determine the intersection of the DEG profiles. DEGs were analyzed by Gene On

SUBMITTER: Ma Y 

PROVIDER: S-EPMC8652394 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature