Dataset Information

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds.

ABSTRACT:

Introduction

The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated.

Methods

We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)₄₂, Aβ₄₀, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ₄₂/Aβ₄₀ ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele.

Results

Serum urate was positively associated with Aβ₄₂ in males (β = 0.55 pg/mL, P = .04). There was a positive urate-APOE ε4 interaction (1.24 pg/mL, P _interaction = .02) in relation to Aβ₄₂ association. The positive urate and Aβ₄₂ association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P = .01).

Discussion

The positive association between urate and Aβ₄₂ in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.

SUBMITTER: Fatima T

PROVIDER: S-EPMC8652407 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds.

Fatima Tahzeeb T Jacobsson Lennart T H LTH Kern Silke S Zettergren Anna A Blennow Kaj K Zetterberg Henrik H Johansson Lena L Dehlin Mats M Skoog Ingmar I

Alzheimer's & dementia (Amsterdam, Netherlands) 20211208 1

<h4>Introduction</h4>The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated.<h4>Methods</h4>We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)<sub>42</sub>, Aβ<sub>40</sub>, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We a ...[more]

PMID: 34934798

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Dataset Information

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds.

Introduction

Methods

Results

Discussion

Publications

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds.

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