Cognitive screening with functional assessment improves diagnostic accuracy and attenuates bias.

ABSTRACT:

Introduction

Cognitive screening measures often lack sensitivity and are hampered by inequities across ethnoracial groups. A multitrait multimethod (MTMM) classification may attenuate these shortcomings.

Methods

A sample of 7227 participants across the diagnostic spectrum were selected from the National Alzheimer's Coordinating Center cohort. Random forest ensemble methods were used to predict diagnosis across the sample and within Black American (n = 1025) and non-Hispanic White groups (n = 5263) based on: (1) a demographically corrected Montreal Cognitive Assessment (MoCA), (2) MoCA and Functional Assessment Questionnaire (FAQ), (3) MoCA and FAQ with demographic correction.

Results

The MTMM approach with demographic correction had the highest diagnosti

SUBMITTER: Gonzalez DA 

PROVIDER: S-EPMC8652409 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature