Covid-19 vaccination during the third trimester of pregnancy: rate of vaccination and maternal and neonatal outcomes, a multicentre retrospective cohort study.

ABSTRACT:

Objective

To evaluate the impact of Covid-19 vaccination (Pfizer-BioNTech BNT162b2) during the third trimester of pregnancy on maternal and neonatal outcomes.

Design

A multicentre, retrospective computerised database.

Population

Women who gave birth at >24 weeks of gestation in Israel, between January and April 2021, with full records of Covid-19 disease and vaccination status.

Methods

Women who received two doses of the vaccine were compared with unvaccinated women. Women who were recorded as having disease or a positive Covid-19 polymerase chain reaction (PCR) swab during pregnancy or delivery were excluded from both study groups. Univariate analysis was followed by multivariate logistic regression.

Main outcome measures

Composite adverse maternal outc

SUBMITTER: Rottenstreich M 

PROVIDER: S-EPMC8652528 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature