Remote, proactive, telephone based management of toxicity in outpatients during adjuvant or neoadjuvant chemotherapy for early stage breast cancer: pragmatic, cluster randomised trial.

ABSTRACT:

Objective

To evaluate the effectiveness of remote proactive management of toxicities during chemotherapy for early stage breast cancer.

Design

Pragmatic, cluster randomised trial.

Setting

20 cancer centres in Ontario, Canada, allocated by covariate constrained randomisation to remote management of toxicities or routine care.

Participants

All patients starting adjuvant or neoadjuvant chemotherapy for early stage breast cancer at each centre. 25 patients from each centre completed patient reported outcome questionnaires.

Interventions

Proactive, standardised, nurse led telephone management of common toxicities at two time points after each chemotherapy cycle.

Main outcome measures

The primary outcome, cluster level mean number of visits to the emerg

SUBMITTER: Krzyzanowska MK 

PROVIDER: S-EPMC8652580 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature