Adolescent cannabis use and adult psychoticism: A longitudinal co-twin control analysis using data from two cohorts.

ABSTRACT: Observational studies have repeatedly linked cannabis use and increased risk of psychosis. We sought to clarify whether this association reflects a causal effect of cannabis exposure or residual confounding. We analyzed data from two cohorts of twins who completed repeated, prospective measures of cannabis use (N = 1544) and cannabis use disorder symptoms (N = 1458) in adolescence and a dimensional measure of psychosis-proneness (the Personality Inventory for DSM-5 Psychoticism scale) in adulthood. Twins also provided molecular genetic data, which were used to estimate polygenic risk of schizophrenia. Both cumulative adolescent cannabis use and use disorder were associated with higher Psychoticism scores in adulthood. However, we found no evidence of an effect of canna

SUBMITTER: Schaefer JD 

PROVIDER: S-EPMC8652585 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature