COVID-19 Vaccine Response in People with Multiple Sclerosis.

ABSTRACT:

Objective

The purpose of this study was to investigate the effect of disease modifying therapies on immune response to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines in people with multiple sclerosis (MS).

Methods

Four hundred seventy-three people with MS provided one or more dried blood spot samples. Information about coronavirus disease 2019 (COVID-19) and vaccine history, medical, and drug history were extracted from questionnaires and medical records. Dried blood spots were eluted and tested for antibodies to SARS-CoV-2. Antibody titers were partitioned into tertiles with people on no disease modifying therapy as a reference. We calculated the odds ratio of seroconversion (univariate logistic regression) and compared quantitative vaccine response (

SUBMITTER: Tallantyre EC 

PROVIDER: S-EPMC8652739 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature