CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis.

ABSTRACT:

Background

Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data.

Objective

To test the long-term clinical and radiological prognostic value of cerebrospinal fluid (CSF)-NfL among newly diagnosed patients with MS.

Methods

Newly diagnosed MS patients where followed prospectively with baseline CSF-NfL and repeated MRI and clinical assessments for up to 10 years. Associations between baseline CSF-NfL and longitudinal MRI and clinical assessments were found by Generalized Estimating Equations analysis.

Results

Forty-two participants were included. CSF-NfL at baseline was significantly associated with the rate of atrophy in globus pallidus (p = 0.009) and hippocam

SUBMITTER: Bhan A 

PROVIDER: S-EPMC8652913 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature