Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

ABSTRACT:

Background

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important.

Methods

In this study, we analyzed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding

SUBMITTER: Gattinger P 

PROVIDER: S-EPMC8653362 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature