Ontology highlight
ABSTRACT:
SUBMITTER: Sahni V
PROVIDER: S-EPMC8653526 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Sahni Vibhu V Shnider Sara J SJ Jabaudon Denis D Song Janet H T JHT Itoh Yasuhiro Y Greig Luciano C LC Macklis Jeffrey D JD
Cell reports 20211001 3
For precise motor control, distinct subpopulations of corticospinal neurons (CSN) must extend axons to distinct spinal segments, from proximal targets in the brainstem and cervical cord to distal targets in thoracic and lumbar spinal segments. We find that developing CSN subpopulations exhibit striking axon targeting specificity in spinal white matter, which establishes the foundation for durable specificity of adult corticospinal circuitry. Employing developmental retrograde and anterograde lab ...[more]