Longitudinal risk factors for developing depressive symptoms in Parkinson's disease.

ABSTRACT:

Background

Despite the established importance of identifying depression in Parkinson's disease, our understanding of the factors which place the Parkinson's disease patient at future risk of depression is limited.

Methods

Our sample consisted of 874 patients from two longitudinal cohorts, PPMI and PDBP, with median follow-up durations of 7 and 3 years respectively. Risk factors for depressive symptoms at baseline were determined using logistic regression. A Cox regression model was then used to identify baseline factors that predisposed the non-depressed patient to develop depressive symptoms that were sustained for at least one year, while adjusting for antidepressant use and cognitive impairment. Common predictors between the two cohorts were identified with a random-effec

SUBMITTER: Antar T 

PROVIDER: S-EPMC8653575 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature