Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force.

ABSTRACT:

Importance

Evidence on the relative benefits and harms of primary high-risk human papillomavirus (hrHPV) testing is needed to inform guidelines.

Objective

To inform the US Preventive Services Task Force by modeling the benefits and harms of various cervical cancer screening strategies.

Design, setting, and participants

Microsimulation model of a hypothetical cohort of women initiating screening at age 21 years.

Exposures

Screening with cytology, hrHPV testing, and cytology and hrHPV cotesting, varying age to switch from cytology to hrHPV testing or cotesting (25, 27, 30 years), rescreening interval (3, 5 years), and triage options for hrHPV-positive results (16/18 genotype, cytology testing). Current guidelines-based screening strategies comprised cytology alon

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC8653579 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature