Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.

ABSTRACT:

Background

Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were investigated in the Diabetes Heart Study (DHS), a cohort enriched for type 2 diabetes (T2D).

Methods

The analysis included 700 DHS participants, 438 African Americans (AAs), and 262 European Americans (EAs), in whom coronary artery calcium (CAC) was assessed using ECG-gated computed tomography. Plasma metabolomics using liquid chromatography-mass spectrometry identified 853 known metabolites. An ancestry-specific marginal model incorporating generalized estimating equations examined ass

SUBMITTER: Chevli PA 

PROVIDER: S-EPMC8653597 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature