Clinical phenotypes and prognostic factors of adult-onset Still's disease: data from a large inpatient cohort.

ABSTRACT:

Objectives

To define different clinical phenotypes and assess prognostic factors of adult-onset Still's disease (AOSD).

Methods

Overall, 492 patients with AOSD seen between 2004 and 2018 at a single centre were retrospectively studied.

Results

Of these patients, 78% were female, and the median age at onset was 34 (25-49) years [median (25th-75th percentile)]. The median follow-up time was 7 (3-10) years [median (25th-75th percentile)]. Clinical manifestations at admission were used to subdivide patients with AOSD as follows: systemic inflammation (cluster 1), pure (cluster 2), and intermediate (cluster 3). Each subtype had distinct clinical manifestations and prognoses: cluster 1 (34.6%)-multiple organ manifestations, highest infection rate and mortality, and more tha

SUBMITTER: Li R 

PROVIDER: S-EPMC8653615 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature