Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals.

ABSTRACT:

Rational

To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate and mortality in COVID-19 patients admitted to intensive care units (ICUs).

Methods

Multicenter, prospective cohort study (COVID-ICU) in 137 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, oxygenation failure, and survival data were collected. Oxygenation failure was defined as either intubation or death in the ICU without intubation. Variables independently associated with oxygenation failure and Day-90 mortality were assessed using multivariate logistic regression.

Results

From February 25 to May 4, 2020, 4754 patients were admitted in ICU. Of these, 1491 patients were n

SUBMITTER: COVID-ICU group, for the REVA network, COVID-ICU investigators 

PROVIDER: S-EPMC8653629 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature