Hydrogen peroxide-producing electrochemical bandage controlled by a wearable potentiostat for treatment of wound infections.

ABSTRACT: Chronic wound infections caused by biofilm-forming microorganisms represent a major burden to healthcare systems. Treatment of chronic wound infections using conventional antibiotics is often ineffective due to the presence of bacteria with acquired antibiotic resistance and biofilm-associated antibiotic tolerance. We previously developed an electrochemical scaffold that generates hydrogen peroxide (H₂ O₂ ) at low concentrations in the vicinity of biofilms. The goal of this study was to transition our electrochemical scaffold into an H₂ O₂ -generating electrochemical bandage (e-bandage) that can be used in vivo. The developed e-bandage uses a xanthan gum-based hydrogel to maintain electrolytic conductivity between e-bandage electrodes and biofilm

SUBMITTER: Mohamed A 

PROVIDER: S-EPMC8653773 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature