Targeted Next-Generation Sequencing Identifies Pathogenic Variants in Diabetic Kidney Disease.

ABSTRACT:

Introduction

Diabetes is the most common cause of chronic kidney disease (CKD). For patients with diabetes and CKD, the underlying cause of their kidney disease is often assumed to be a consequence of their diabetes. Without histopathological confirmation, however, the underlying cause of their disease is unclear. Recent studies have shown that next-generation sequencing (NGS) provides a promising avenue toward uncovering and establishing precise genetic diagnoses in various forms of kidney disease.

Methods

Here, we set out to investigate the genetic basis of disease in nondiabetic kidney disease (NDKD) and diabetic kidney disease (DKD) patients by performing targeted NGS using a custom panel comprising 345 kidney disease-related genes.

Results

Our analysis identified

SUBMITTER: Lazaro-Guevara J 

PROVIDER: S-EPMC8653779 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature