Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children's Immune Health.

ABSTRACT: Owing to their significant impact on children's long-term health, familial factors in the microbiomes of children have attracted increasing attention. However, the mechanism underlying microbiome transmission across generations remains unclear. A significantly lower alpha diversity was observed in the gut flora of children than in the gut flora of parents and grandparents; the alpha diversity of oral and skin microbiota was relatively higher in children than in their predecessors. Gut, oral, and skin microbiome was more similar between family members than between unrelated individuals. Meanwhile, 55.05%, 61.09%, and 76.73% of amplicon sequence variants (ASVs) in children's gut, oral, and skin microbiomes, respectively, were transmitted from all family members. Among these, the most transmi

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8653841 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature