Endothelin Receptor Antagonists as a Potential Treatment of Diabetic Nephropathy: A Systematic Review.

ABSTRACT: Diabetic nephropathy is becoming a more predominant cause of end-stage renal disease, as the prevalence of diabetes mellitus worldwide is on the rise. In this systematic review, we aimed to define the role of endothelin receptor antagonists, in the prevention and treatment of diabetic nephropathy, in addition to determining their safety. For this review, PubMed, Google Scholar, and Cochrane Library databases, in addition to ClinicalTrials.gov, were searched for publications in the last 20 years. We included 14 studies, seven randomized control trials, and seven post hoc analyses in this paper. Atrasentan decreased albuminuria, reduced blood pressure, and improved lipid profiles with more manageable fluid overload-related adverse events than avosentan and bosentan. Overall, endothelin recep

SUBMITTER: Ahmad N 

PROVIDER: S-EPMC8653857 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature