Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues.

ABSTRACT:

Background

Dopamine neurotransmission plays a critical role in reward in drug abuse and drug addiction. However, the role of dopamine in the recognition of drug-associated environmental stimuli, retrieval of drug-associated memory, and drug-seeking behaviors is not fully understood.

Methods

Roles of dopamine neurotransmission in the prefrontal cortex (PFC) and nucleus accumbens (NAc) in the cocaine-conditioned place preference (CPP) paradigm were evaluated using in vivo microdialysis.

Results

In mice that had acquired cocaine CPP, dopamine levels in the PFC, but not in the NAc, increased in response to cocaine-associated cues when mice were placed in the cocaine chamber of an apparatus with 2 separated chambers. The induction of the dopamine response and the developme

SUBMITTER: Kawahara Y 

PROVIDER: S-EPMC8653875 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature