Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction.

ABSTRACT: Fertilization in mammals begins with the union of egg and sperm, an event that starts a cascade of cellular processes. The molecular-level understanding of these processes can guide the development of new strategies for controlling and/or promoting fertilization, and inform researchers and medical professional on the best choice of interventions. The proteins encoded by the IZUMO1 and JUNO genes form a ligand-receptor protein pair involved in the recognition of sperm and egg. Due to their role in the fertilization process, these proteins are potential targets for the development of novel anti-contraceptive, as well as infertility treatments. Here we present a comprehensive analysis of these gene sequences, with the objective of identifying evolutionary patterns that may support their relev

SUBMITTER: Allingham J 

PROVIDER: S-EPMC8654184 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature