Integrated analysis of the functions and prognostic values of RNA-binding proteins in neuroblastoma.

ABSTRACT:

Background

Neuroblastoma (NB) is the most common solid tumor in children. NB treatment has made significant progress; however, given the high degree of heterogeneity, basic research findings and their clinical application to NB still face challenges. Herein, we identify novel prognostic models for NB.

Methods

We obtained RNA expression data of NB and normal nervous tissue from TARGET and GTEx databases and determined the differential expression patterns of RNA binding protein (RBP) genes between normal and cancerous tissues. Lasso regression and Cox regression analyses identified the five most important differentially expressed genes and were used to construct a new prognostic model. The function and prognostic value of these RBPs were systematically studied and the predicti

SUBMITTER: Yang J 

PROVIDER: S-EPMC8654225 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature