Orthopaedic Gene Therapy: Twenty-Five Years On.

ABSTRACT:

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Orthopaedics pioneered the expansion of gene therapy beyond its traditional scope of diseases that are caused by rare single-gene defects. Orthopaedic applications of gene therapy are most developed in the areas of arthritis and regenerative medicine, but several additional possibilities exist.

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Invossa, an ex vivo gene therapeutic for osteoarthritis, was approved in South Korea in 2017, but its approval was retracted in 2019 and remains under appeal; a Phase-III clinical trial of Invossa has restarted in the U.S.

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There are several additional clinical trials for osteoarthritis and rheumatoid arthritis that could lead to approved gene therapeutics for arthritis.

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Bone-healing and cartilage repair are additional areas that are attracting considerable resear

SUBMITTER: Evans CH 

PROVIDER: S-EPMC8654240 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature