HIV-1 drug resistance and genetic diversity in a cohort of people with HIV-1 in Nigeria.

ABSTRACT:

Objective

This study was designed to provide information on the genetic diversity of HIV-1 and drug resistance mutations in Nigeria, as there is limited understanding of variants circulating in the country.

Methods

We used an advanced next-generation sequencing platform, Primer ID, to: investigate the presence of high and low abundance drug resistance mutations; characterize preexisting Integrase Strand Transfer Inhibitor (INSTI) mutations in antiretroviral therapy (ART)-experienced but dolutegravir-naive individuals; detect recent HIV-1 infections and characterize subtype diversity from a cohort of people with HIV-1 (PWH).

Results

HIV-1 subtype analysis revealed the predominance of CRF02_AG and subtype G in our study population. At detection sensitivity of 30% abunda

SUBMITTER: Oluniyi PE 

PROVIDER: S-EPMC8654252 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature