Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats.

ABSTRACT:

Background

The renal tissue renin-angiotensin system is known to be activated by salt loading in salt-sensitive rats; however, the response in other organs remains unclear.

Method

Spontaneously hypertensive rats were subjected to normal tap water or transient high-salt-concentration water from 6 to 14 weeks of age and were thereafter given normal tap water. From 18 to 20 weeks of age, rats given water with a high salt concentration were treated with an angiotensin II type 1 receptor blocker, valsartan.

Results

Sustained blood pressure elevation by transient salt loading coincided with a persistent decrease in the fecal sodium content and sustained excess of the circulating volume in spontaneously hypertensive rats. Administration of valsartan sustainably reduced the b

SUBMITTER: Ryuzaki M 

PROVIDER: S-EPMC8654260 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature